| Required class | Vampire |
| Knowledge category | Blood Rune |
| Required powers | Path of Shadows 1+ |
The Sanguine rune represents the vampiric blood from which you draw your power.
When placed on your cheeks, this rune enhances your Blood Legacy. While using Puissance, you gain +1 physical bypass per rank. While using Swiftness, you gain +1 Speed and movement per rank. While using Fortitude, you gain +2% spell armour per rank. Your bites (including bursts and Bat Form attacks) also gain +1 bypass per rank. Your lowest rank of Blood Runes and Blood Legacy is used.
When placed on your chest, this rune draws upon the power of any bloodsteel you are wearing in order to strengthen and protect your internals. While affected by Blood Taint, you gain +2% natural internal armour vs all damage types for each rank in each of Blood Runes, Blood Forging and Blood Legacy.
When placed on your hands and wearing blood tainted items, this rune allows you to channel energy from your other runes. If you have an Ember rune, your hands will gain fire burst as if they had the Ember hands rune, while Thunder gives shock and Umbrage cold. If you have two such runes, the secondary caps at rank
When placed on your feet, this rune causes your blood to rapidly adapt your body in response to damage. You receive +2% armour vs one physical damage type and +1% armour vs one energy damage type, per rank, although this cannot exceed your rank in Blood Forging. These two damage types will change every time you receive physical or energy damage of a different type.